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Clinical Virology

The research activities of the department are funded by a number of extramural and intramural grants. Outlined below are the projects in various specialty areas.

In the field of retro virology and opportunistic viruses:

  • A study of mutations in the pol gene of human immunodeficiency virus-type1 (HIV-1) of treatment naive and treatment experienced individuals are being studied from which three dimensional computational models will be constructed to analyse drug affinity of various drugs to these virus mutants (Funding : ICMR).
  • Emergence of polymorphisms indicating drug resistance in the reverse transcriptase gene of HIV-1 in pregnant women before and after prophylaxis to prevent mother to child HIV-1 transmission is also being studied (Funding : ICMR).
  • A comparison of the quantification of HIV-1 from dried blood spots versus plasma (Funding : intramural)
  • Intestinal dysfunction at the time of initiation of HAART as a potential risk factor for drug malabsorption and treatment failure (Funding: Fogarty International Centre of NIH)*
  • Antiretroviral therapy adherence in the public health model of HIV care (Funding: Tufts University)*
  • A study on the virological and immunological aspects associated with opportunistic viral infections in HIV-1 infected individuals in India (south)( Funding: intramural)
  • A study to determine the prevalence of Epstein Barr virus (EBV) infection by detecting mRNA for EB Nuclear antigen 1 in histologically proven cases of gastric adenocarcinoma (Funding : intramural) *

In the field of respiratory viral infections:

  • A multi-site influenza surveillance study involving the detection of influenza A and B viruses among patients presenting with influenza-like illness and severe acute respiratory infection(Funding : CDC and ICMR).
  • A multi-centric study looking at infuenza burden of disease in the general population �different measures of an estimate of morbidity and mortality due to influenza will be made in the community (Funding : CDC)
  • A study to determine the aetiology of lower respiratory infections in children under 5 years of age which includes the whole range of respiratory viruses (Funding : ICMR)

In the field of hepatovirology:

  • An investigation into certain genetic and immunological (HLA, MBL2,TLR and IFN-γ) factors that influence the outcome of hepatitis B virus (HBV) infection in south Indian Individuals (Funding : DBT)
  • Characterization of hepatitis B virus drug resistance in Indian subcontinent patients (Funding: ICMR)
  • Evaluation of a hand-held microPCR for quantification of HBV and HCV (Funding : BigTec Pvt. Ltd)

In the field of papillomaviruses (HPV):

  • HPV infection in HIV sero-positive men (Funding : NIH & ICMR)
  • A life style approach to Head and Neck cancers – role of HPV (Funding : Recherche Scientifique Institute, Canada)*
  • Assessment of the prevalence of HPV in oral cavity of patients with oral cancers and asymptomatic individuals (Funding : intramural)*

*Co-investigator status