Varghese J, James J, Vaulont S, Mckie A, Jacob M. Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1870-1882. doi: 10.1016/j.bbagen.2018.05.022. Epub 2018 May 31. PMID: 29859963; PMCID: PMC6029669. Link

Jacob M, Jacob KS. Medicine, medical writing, and India. Indian J Psychiatry. 2016 Jul-Sep;58(3):332-335. doi: 10.4103/0019-5545.191993. PMID: 28066014; PMCID: PMC5100128. Link

Varghese J, James JV, Sagi S, Chakraborty S, Sukumaran A, Ramakrishna B, Jacob M. Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. Br J Nutr. 2016 Jun;115(11):1978-86. doi: 10.1017/S0007114516001197. Epub 2016 Apr 15. PMID: 27080262.

Sukumaran A, James J, Janardhan HP, Amaladas A, Suresh LM, Danda D, Jeyeseelan V, Ramakrishna BS, Jacob M. Expression of iron-related proteins in the duodenum is up-regulated in patients with chronic inflammatory disorders. Br J Nutr. 2014 Mar 28;111(6):1059-68. doi: 10.1017/S0007114513003334. Epub 2013 Oct 25. PMID: 24160450. Link

Somasundaram S, Rafi S, Jacob M, Sigthorsson G, Mahmud T, Sherwood R, Price AB, Macpherson A, Scott D, Wrigglesworth JM, Bjarnason I. Intestinal tolerability of nitroxybutyl-flurbiprofen in rats. Gut. 1997 May;40(5):608-13. doi: 10.1136/gut.40.5.608. PMID: 9203938; PMCID: PMC1027162. Link

Patel N, Varghese J, Masaratana P, Latunde-Dada GO, Jacob M, Simpson RJ, McKie AT. The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels. Br J Haematol. 2014 Feb;164(4):586-96. doi: 10.1111/bjh.12649. Epub 2013 Nov 16. PMID: 24236640; PMCID: PMC4232863.

Varghese J, James J, Vaulont S, Mckie A, Jacob M. Increased intracellular iron in mouse primary hepatocytes in vitro causes activation of the Akt pathway but decreases its response to insulin. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1870-1882. doi: 10.1016/j.bbagen.2018.05.022. Epub 2018 May 31. PMID: 29859963; PMCID: PMC6029669. Link

Jacob M, Jacob KS. Medicine, medical writing, and India. Indian J Psychiatry. 2016 Jul-Sep;58(3):332-335. doi: 10.4103/0019-5545.191993. PMID: 28066014; PMCID: PMC5100128. Link

Varghese J, James JV, Sagi S, Chakraborty S, Sukumaran A, Ramakrishna B, Jacob M. Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. Br J Nutr. 2016 Jun;115(11):1978-86. doi: 10.1017/S0007114516001197. Epub 2016 Apr 15. PMID: 27080262.

Sukumaran A, James J, Janardhan HP, Amaladas A, Suresh LM, Danda D, Jeyeseelan V, Ramakrishna BS, Jacob M. Expression of iron-related proteins in the duodenum is up-regulated in patients with chronic inflammatory disorders. Br J Nutr. 2014 Mar 28;111(6):1059-68. doi: 10.1017/S0007114513003334. Epub 2013 Oct 25. PMID: 24160450. Link

Somasundaram S, Rafi S, Jacob M, Sigthorsson G, Mahmud T, Sherwood R, Price AB, Macpherson A, Scott D, Wrigglesworth JM, Bjarnason I. Intestinal tolerability of nitroxybutyl-flurbiprofen in rats. Gut. 1997 May;40(5):608-13. doi: 10.1136/gut.40.5.608. PMID: 9203938; PMCID: PMC1027162. Link

Patel N, Varghese J, Masaratana P, Latunde-Dada GO, Jacob M, Simpson RJ, McKie AT. The transcription factor ATOH8 is regulated by erythropoietic activity and regulates HAMP transcription and cellular pSMAD1,5,8 levels. Br J Haematol. 2014 Feb;164(4):586-96. doi: 10.1111/bjh.12649. Epub 2013 Nov 16. PMID: 24236640; PMCID: PMC4232863.

Varghese J, Jacob M. Do medical students require education on issues related to plagiarism? Indian J Med Ethics. 2015 Apr-Jun;12(2):82-7. doi: 10.20529/IJME.2015.026. Epub 2014 Nov 25. PMID: 25671582.

Sukumaran A, Varghese J, Tamilselvan J, Jeyaseelan V, Mani T, Simpson RJ, McKie AT, Jacob M. Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: a time-course study. Br J Nutr. 2012 Dec 14;108(11):1994-2001. doi: 10.1017/S0007114512000189. Epub 2012 Feb 24. PMID: 22360813.

Sukumaran A, Venkatraman A, Jacob M. Inflammation-induced effects on iron-related proteins in splenic macrophages and the liver in mice. Blood Cells Mol Dis. 2012 Jun 15;49(1):11-9. doi: 10.1016/j.bcmd.2012.03.002. Epub 2012 Apr 14. PMID: 22504041.

Sigthorsson G, Jacob M, Wrigglesworth J, Somasundaram S, Tavares I, Foster R, Roseth A, Rafi S, Mahmud T, Simpson R, Bjarnason I. Comparison of indomethacin and nimesulide, a selective cyclooxygenase-2 inhibitor, on key pathophysiologic steps in the pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in the rat. Scand J Gastroenterol. 1998 Jul;33(7):728-35. doi: 10.1080/00365529850171675. PMID: 9712237.

Jacob M, Bjarnason I, Simpson RJ. Effects of indomethacin on energy metabolism in rat and human jejunal tissue in vitro. Clin Sci (Lond). 2001 Nov;101(5):493-8. PMID: 11672454. Link

Jacob M, Bjarnason I, Simpson RJ. Effects of indomethacin on energy metabolism in rat jejunal tissue in vivo. Clin Sci (Lond). 2002 May;102(5):541-6. PMID: 11980573.

Basivireddy J, Jacob M, Balasubramanian KA. Oral glutamine attenuates indomethacin-induced small intestinal damage. Clin Sci (Lond). 2004 Sep;107(3):281-9. doi: 10.1042/CS20030390. PMID: 15128285.

Jacob M, Bjarnason I, Simpson RJ. Effects of indomethacin on mitochondrial ATP synthesis. Biochem Soc Trans. 1998 May;26(2):S161. doi: 10.1042/bst026s161. PMID: 9649836.

Jacob M, Bjarnason I, Simpson RJ. Effects of indomethacin on mitochondrial oxygen uptake in intestine. Biochem Soc Trans. 1998 May;26(2):S162. doi: 10.1042/bst026s162. PMID: 9649837.

Jacob M, Bjarnason I, Simpson RJ. In vitro evidence for mitochondrial effects of indomethacin. Biochem Soc Trans. 1998 Nov;26(4):S315. doi: 10.1042/bst026s315. PMID: 10047829.

Basivireddy J, Vasudevan A, Jacob M, Balasubramanian KA. Indomethacin-induced mitochondrial dysfunction and oxidative stress in villus enterocytes. Biochem Pharmacol. 2002 Jul 15;64(2):339-49. doi: 10.1016/s0006-2952(02)01067-5. PMID: 12123755.

Basivireddy J, Jacob M, Pulimood AB, Balasubramanian KA. Indomethacin-induced renal damage: role of oxygen free radicals. Biochem Pharmacol. 2004 Feb 1;67(3):587-99. doi: 10.1016/j.bcp.2003.09.023. PMID: 15037210.

Basivireddy J, Jacob M, Balasubramanian KA. Indomethacin induces free radical-mediated changes in renal brush border membranes. Arch Toxicol. 2005 Aug;79(8):441-50. doi: 10.1007/s00204-005-0658-4. Epub 2005 May 12. PMID: 15889237.

Jacob M, Foster R, Sigthorsson G, Simpson R, Bjarnason I. Role of bile in pathogenesis of indomethacin-induced enteropathy. Arch Toxicol. 2007 Apr;81(4):291-8. doi: 10.1007/s00204-006-0149-2. Epub 2006 Dec 7. PMID: 17151867.

Jayasree Basivireddy, Molly Jacob, Prabhu Ramamoorthy, Anna B. Pulimood, Kunissery A. Balasubramanian Indomethacin-induced free radical-mediated changes in the intestinal brush border membranes, Biochemical Pharmacology, Volume 65, Issue 4, 2003, Pages 683-695, https://doi.org/10.1016/S0006-2952(02)01616-7.

Sivalingam N, Basivireddy J, Pulimood AB, Balasubramanian KA, Jacob M. Activation of phospholipase A2 is involved in indomethacin-induced damage in Caco-2 cells. Toxicol In Vitro. 2009 Aug;23(5):887-96. doi: 10.1016/j.tiv.2009.05.008. Epub 2009 May 24. PMID: 19470405

Somasundaram S, Sigthorsson G, Simpson RJ, Watts J, Jacob M, Tavares IA, Rafi S, Roseth A, Foster R, Price AB, Wrigglesworth JM, Bjarnason I. Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat. Aliment Pharmacol Ther. 2000 May;14(5):639-50. doi: 10.1046/j.1365-2036.2000.00723.x. PMID: 10792129.

Jacob M, Bjarnason I, Rafi S, Wrigglesworth J, Simpson RJ. A study of the effects of indometacin on liver mitochondria from rats, mice and humans. Aliment Pharmacol Ther. 2001 Nov;15(11):1837-42. doi: 10.1046/j.1365-2036.2001.01095.x. PMID: 11683698.

Somasundaram S, Rafi S, Hayllar J, Sigthorsson G, Jacob M, Price AB, Macpherson A, Mahmod T, Scott D, Wrigglesworth JM, Bjarnason I. Mitochondrial damage: a possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine. Gut. 1997 Sep;41(3):344-53. doi: 10.1136/gut.41.3.344. PMID: 9378390; PMCID: PMC1891477.

Mahmud T, Somasundaram S, Sigthorsson G, Simpson RJ, Rafi S, Foster R, Tavares IA, Roseth A, Hutt AJ, Jacob M, Pacy J, Scott DL, Wrigglesworth JM, Bjarnason I. Enantiomers of flurbiprofen can distinguish key pathophysiological steps of NSAID enteropathy in the rat. Gut. 1998 Dec;43(6):775-82. doi: 10.1136/gut.43.6.775. PMID: 9824604; PMCID: PMC1727351.

Natarajan SK, Basivireddy J, Ramachandran A, Thomas S, Ramamoorthy P, Pulimood AB, Jacob M, Balasubramanian KA. Renal damage in experimentally-induced cirrhosis in rats: Role of oxygen free radicals. Hepatology. 2006 Jun;43(6):1248-56. doi: 10.1002/hep.21179. PMID: 16729302.

Nagappan AS, Varghese J, James JV, Jacob M. Indomethacin induces endoplasmic reticulum stress, but not apoptosis, in the rat kidney. Eur J Pharmacol. 2015 Aug 15;761:199-205. doi: 10.1016/j.ejphar.2015.04.044. Epub 2015 May 7. PMID: 25958182.

Varghese J, Faith M, Jacob M. Zinc prevents indomethacin-induced renal damage in rats by ameliorating oxidative stress and mitochondrial dysfunction. Eur J Pharmacol. 2009 Jul 1;614(1-3):114-21. doi: 10.1016/j.ejphar.2009.04.053. Epub 2009 May 13. PMID: 19445918. Link

Sivalingam N, Pichandi S, Chapla A, Dinakaran A, Jacob M. Zinc protects against indomethacin-induced damage in the rat small intestine. Eur J Pharmacol. 2011 Mar 1;654(1):106-16. doi: 10.1016/j.ejphar.2010.12.014. Epub 2010 Dec 24. PMID: 21185825.

Rajkumar AP, Poonkuzhali B, Kuruvilla A, Srivastava A, Jacob M, Jacob KS. Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia. Psychopharmacology (Berl). 2012 Dec;224(3):441-9. doi: 10.1007/s00213-012-2773-2. Epub 2012 Jun 15. PMID: 22700043.

Jacob M, Wilfred G, Kanagasabapathy AS, Balasubramaniam N. Urinary N-acetyl-beta-D-glucosaminidase in the prediction of preeclampsia and pregnancy-induced hypertension. Aust N Z J Obstet Gynaecol. 1993 Nov;33(4):395-7. doi: 10.1111/j.1479-828x.1993.tb02119.x. PMID: 8179551. Link

Jacob M, Balasubramaniam N. Excretion of urinary enzymes in normal pregnancy. Clin Biochem. 2006 Jul;39(7):754-7. doi: 10.1016/j.clinbiochem.2006.03.011. Epub 2006 Apr 3. PMID: 16690046.

Faith M, Eapen CE, Wilfred G, Ramachandran J, Jacob M. Serum biotinidase is a sensitive and specific biochemical marker of hepatic dysfunction: A preliminary report. Hepatol Res. 2007 Jan;37(1):13-7. doi: 10.1111/j.1872-034X.2007.00002.x. PMID: 17300694. Link

Nagappan AS, Varghese J, Pranesh GT, Jeyaseelan V, Jacob M. Indomethacin inhibits activation of endothelial nitric oxide synthase in the rat kidney: possible role of this effect in the pathogenesis of indomethacin-induced renal damage. Chem Biol Interact. 2014 Sep 25;221:77-87. doi: 10.1016/j.cbi.2014.07.014. Epub 2014 Aug 8. PMID: 25110317.

Rajagopal VM, Rajkumar AP, Jacob KS, Jacob M. Gene-gene interaction between DRD4 and COMT modulates clinical response to clozapine in treatment-resistant schizophrenia. Pharmacogenet Genomics. 2018 Jan;28(1):31-35. doi: 10.1097/FPC.0000000000000314. PMID: 29087970.

Faith M, Sukumaran A, Pulimood AB, Jacob M. How reliable an indicator of inflammation is myeloperoxidase activity? Clin Chim Acta. 2008 Oct;396(1-2):23-5. doi: 10.1016/j.cca.2008.06.016. Epub 2008 Jun 21. PMID: 18619953.

Sivalingam N, Basivireddy J, Balasubramanian KA, Jacob M. Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. Arch Toxicol. 2008 Jul;82(7):471-81. doi: 10.1007/s00204-007-0263-9. Epub 2007 Nov 30. PMID: 18060385.

Varghese J, Faith M, Jacob M. Impact of e-resources on learning in biochemistry: first-year medical students' perceptions. BMC Med Educ. 2012 May 16;12:21. doi: 10.1186/1472-6920-12-21. PMID: 22510159; PMCID: PMC3353857.

James JV, Varghese J, Mckie AT, Vaulont S, Jacob M. Enhanced insulin signaling and its downstream effects in iron-overloaded primary hepatocytes from hepcidin knock-out mice. Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118621. doi: 10.1016/j.bbamcr.2019.118621. Epub 2019 Dec 5. PMID: 31812496. Link

Rajkumar AP, Poonkuzhali B, Kuruvilla A, Srivastava A, Jacob M, Jacob KS. Association between CYP1A2 gene single nucleotide polymorphisms and clinical responses to clozapine in patients with treatment-resistant schizophrenia. Acta Neuropsychiatr. 2013 Feb;25(1):2-11. doi: 10.1111/j.1601-5215.2012.00638.x. PMID: 26953068. Link

Varghese J, Varghese James J, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE, Jacob M. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2020 Mar;58:126442. doi: 10.1016/j.jtemb.2019.126442. Epub 2019 Nov 28. PMID: 31835128.

Rajkumar AP, Poonkuzhali B, Kuruvilla A, Jacob M, Jacob KS. Clinical predictors of serum clozapine levels in patients with treatment-resistant schizophrenia. Int Clin Psychopharmacol. 2013 Jan;28(1):50-6. doi: 10.1097/YIC.0b013e32835ac9da. PMID: 23104241.

Basivireddy J, Jacob M, Ramamoorthy P, Balasubramanian KA. Alterations in the intestinal glycocalyx and bacterial flora in response to oral indomethacin. Int J Biochem Cell Biol. 2005 Nov;37(11):2321-32. doi: 10.1016/j.biocel.2005.05.010. PMID: 15979923.

Jacob M, Simpson R, Bjarnason I. Non steroidal anti-inflammatory drugs, cyclooxygenase selectivity and gastrointestinal toxicity. Ital J Gastroenterol Hepatol. 1998 Feb;30(1):12-8. PMID: 9615258.

Sivalingam N, Hanumantharaya R, Faith M, Basivireddy J, Balasubramanian KA, Jacob M. Curcumin reduces indomethacin-induced damage in the rat small intestine. J Appl Toxicol. 2007 Nov-Dec;27(6):551-60. doi: 10.1002/jat.1235. PMID: 17351913.

Patel N, Masaratana P, Diaz-Castro J, Latunde-Dada GO, Qureshi A, Lockyer P, Jacob M, Arno M, Matak P, Mitry RR, Hughes RD, Dhawan A, Patterson C, Simpson RJ, McKie AT. BMPER protein is a negative regulator of hepcidin and is up-regulated in hypotransferrinemic mice. J Biol Chem. 2012 Feb 3;287(6):4099-106. doi: 10.1074/jbc.M111.310789. Epub 2011 Dec 5. PMID: 22144676; PMCID: PMC3281740.

Rajagopal V, Sundaresan L, Rajkumar AP, Chittybabu C, Kuruvilla A, Srivastava A, Balasubramanian P, Jacob KS, Jacob M. Genetic association between the DRD4 promoter polymorphism and clozapine-induced sialorrhea. Psychiatr Genet. 2014 Dec;24(6):273-6. doi: 10.1097/YPG.0000000000000058. PMID: 25304228.

Vyas R, Jacob M, Faith M, Isaac B, Rabi S, Sathishkumar S, Selvakumar D, Ganesh A. An effective integrated learning programme in the first year of the medical course. Natl Med J India. 2008 Jan-Feb;21(1):21-6. PMID: 18472699. Link

Dincy CV, George R, Jacob M, Mathai E, Pulimood S, Eapen EP. Clinicopathologic profile of normocomplementemic and hypocomplementemic urticarial vasculitis: a study from South India. J Eur Acad Dermatol Venereol. 2008 Jul;22(7):789-94. doi: 10.1111/j.1468-3083.2007.02641.x. Epub 2008 Mar 7. PMID: 18331318.

Varghese J, James JV, Anand R, Narayanasamy M, Rebekah G, Ramakrishna B, Nellickal AJ, Jacob M. Development of insulin resistance preceded major changes in iron homeostasis in mice fed a high-fat diet. J Nutr Biochem. 2020 Oct;84:108441. doi: 10.1016/j.jnutbio.2020.108441. Epub 2020 Jun 2. PMID: 32629238; PMCID: PMC7115812.

Ramasamy J, Job V, Mani T, Jacob M. Calculated values of serum LDL-cholesterol (LDL-C) - for better or worse? Nutr Metab Cardiovasc Dis. 2021 May 6;31(5):1486-1493. doi: 10.1016/j.numecd.2021.01.016. Epub 2021 Jan 29. PMID: 33744036.

Varghese GM, Pise G, Michael SJ, Jacob M, George R. Disseminated Penicillium marneffei infection in a human immunodeficiency virus-infected individual. J PostgrAA

Rupa V, Jacob M, Mathews MS. Atopy, proptosis, and nasal polyposis. Allergic fungal sinusitis with proptosis. Postgrad Med J. 2001 May;77(907):343, 350-2. doi: 10.1136/pmj.77.907.343. PMID: 11320286; PMCID: PMC1742035.

Rupa V, Jacob M, Mathews MS, Job A, Kurien M, Chandi SM. Clinicopathological and mycological spectrum of allergic fungal sinusitis in South India. Mycoses. 2002 Nov;45(9-10):364-7. doi: 10.1046/j.1439-0507.2002.00784.x. PMID: 12421282.

Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics. J Diabetes Complications. 2021 Sep;35(9):107977. doi: 10.1016/j.jdiacomp.2021.107977. Epub 2021 Jun 19. PMID: Venkatesan P, Varghese J, Arthi TS, James JV, Anura A, Prasad J, Jacob M. Evidence of dysregulated iron homeostasis in newly diagnosed diabetics, but not in pre-diabetics. J Diabetes Complications. 2021 Sep;35(9):107977. doi: 10.1016/j.jdiacomp.2021.107977. Epub 2021 Jun 19. PMID: 34217587 Link

James JV, Varghese J, John NM, Deschemin JC, Vaulont S, McKie AT, Jacob M. Insulin resistance and adipose tissue inflammation induced by a high-fat diet are attenuated in the absence of hepcidin. J Nutr Biochem. 2023 Jan;111:109175. doi: 10.1016/j.jnutbio.2022.109175. Epub 2022 Oct 9. PMID: 36223834.

Varghese J, Jacob M. Gift authorship: Look the gift horse in the mouth. Indian J Med Ethics. 2022 Jul-Sep;VII(3):196-202. doi: 10.20529/IJME.2022.028. Epub 2022 Apr 21. PMID: 35699293.

Ramasamy J, Job V, Mani T, Jacob M. Calculated values of serum LDL-cholesterol (LDL-C) - for better or worse? Nutr Metab Cardiovasc Dis. 2021 May 6;31(5):1486-1493. doi: 10.1016/j.numecd.2021.01.016. Epub 2021 Jan 29. PMID: 33744036.

Jacob M, Jacob KS. Medicine, medical writing, and India. Indian J Psychiatry. 2016 Jul-Sep;58(3):332-335. doi: 10.4103/0019-5545.191993. PMID: 28066014; PMCID: PMC5100128.

Varghese J, Varghese James J, Karthikeyan M, Rasalkar K, Raghavan R, Sukumaran A, Premkumar PS, Eapen CE, Jacob M. Iron homeostasis is dysregulated, but the iron-hepcidin axis is functional, in chronic liver disease. J Trace Elem Med Biol. 2020 Mar;58:126442. doi: 10.1016/j.jtemb.2019.126442. Epub 2019 Nov 28. PMID: 31835128. Link

Venkatesan P, Ramasamy J, Vanitha S, Jacob M, Varghese J. Impaired pancreatic beta-cell function after a single dose of oral iron: A before-and-after (pre-post) study. J Hum Nutr Diet. 2023 Jun;36(3):1111-1120. doi: 10.1111/jhn.13074. Epub 2022 Sep 7. PMID: 36000222.

Ramasamy J, Jagadish C, Sukumaran A, Varghese J, Mani T, Joseph AJ, Simon EG, Jacob M. Low Serum Hepcidin Levels in Patients with Ulcerative Colitis - Implications for Treatment of Co-existent Iron-Deficiency Anemia. Inflammation. 2023 Dec;46(6):2209-2222. doi: 10.1007/s10753-023-01872-9. Epub 2023 Jul 24. Erratum in: Inflammation. 2023 Aug 11 PMID: 37486527