Christian Medical College Vellore, Ida Scudder Road, Vellore – 632004, Tamil Nadu, India
Publications
Does oxidative protein damage play a role in the pathogenesis of carbon tetrachloride-induced liver injury in the rat?
Preclinical efficacy of melatonin in the amelioration of tenofovir nephrotoxicity by the attenuation of oxidative stress, nitrosative stress and inflammation in rats
Oxidative damage to the lipids and proteins pf the lungs, testis and kidney of rats during carbon tetrachloride intoxication
A marked decrease in the activity of biotinidase in the plasma of rats after single dose of carbon tetrachloride
Decrease in plasma biotinidase activity with normal albumin concentrations in experimental liver fibrosis
Oxidative damage to the hepatocellular proteins after chronic ethanol intake in the rat
Does oxidative protein damage play a role in the pathogenesis of carbon tetrachloride-induced liver injury in the rat?
Preclinical efficacy of melatonin in the amelioration of tenofovir nephrotoxicity by the attenuation of oxidative stress, nitrosative stress and inflammation in rats
Oxidative damage to the lipids and proteins pf the lungs, testis and kidney of rats during carbon tetrachloride intoxication
A marked decrease in the activity of biotinidase in the plasma of rats after single dose of carbon tetrachloride
Decrease in plasma biotinidase activity with normal albumin concentrations in experimental liver fibrosis
Oxidative damage to the hepatocellular proteins after chronic ethanol intake in the rat
Lysosomal enzyme activity during development of carbon tetrachloride induced cirrhosis in rats
Increased protein thiol in the liver and plasma of rats in acute acetaminophen intoxication
Increased plasma biotinidase activity in rats with paracetamol-induced acute liver injury
Mega dose of vitamin C augments the nephrotoxicity of paracetamol
Nitro-arginine methyl ester, a non-selective inhibitor of nitric oxide synthase reduces ibuprofen-induced gastric mucosal injury in the rat
Propylthiouracil attenuates acetaminophen-induced renal damage in the rat
Vitamin C may be beneficial in the prevention of paracetamol-induced renal damage
Effect of cyclophosphamide treatment on selected lysosomal enzymes in the kidney of rats
Increased glutathione levels and activity of PON1 (phenyl acetate esterase) in the liver of rats after a single dose of cyclophosphamide: a defense mechanism?
Enhanced PON1 activity in the kidneys of cyclophosphamide treated rats may play a protective role as an antioxidant against cyclophosphamide induced oxidative stress
Aminoguanidine, selective nitric oxide synthase inhibitor, ameliorates cyclophosphamide-induced hemorrhagic cystitis by inhibiting protein nitration and PARS activation
Protein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis in the rat
The effects of oral glutamine on cyclophosphamide-induced nephrotoxicity in rats
Oral glutamine attenuates cyclophosphamide-induced oxidative stress in the bladder but does not prevent hemorrhagic cystitis in rats
Ultrastructural changes in the rat kidney after single dose of cyclophosphamide–possible roles for peroxisome proliferation and lysosomal dysfunction in cyclophosphamide-induced renal damage.
Mitochondrial dysfunction and respiratory chain defects in a rodent model of methotrexate-induced enteritis
Preclinical efficacy of melatonin to reduce methotrexate-induced oxidative stress and small intestinal damage in rats
Methotrexate administration induces differential and selective protein tyrosine nitration and cysteine nitrosylation in the subcellular organelles of the small intestinal mucosa of rats
Mitochondrial dysfunction and electron transport chain complex defect in a rat model of tenofovir disoproxil fumarate nephrotoxicity
Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide-induced hemorrhagic cystitis in rat
Melatonin attenuates methotrexate-induced oxidative stress and renal damage in rats
A preclinical study on the protective effect of melatonin against methotrexate-induced small intestinal damage: effect mediated by attenuation of nitrosative stress, protein tyrosine nitration, and PARP activation
Depletion of the cellular antioxidant system contributes to tenofovir disoproxil fumarate – induced mitochondrial damage and increased oxido-nitrosative stress in the kidney
Protective effect of Ebselen, a selenoorganic ding, against Gentamicin induced renal damage in rats.
Teaching in basic sciences – a novel approach. Integrated case based learning
Methotrexate-induced nitrosative stress may play a critical role in small intestinal damage in the rat
Protein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis in the rat
Decreased activity of hepatic alkaline protease in rats with carbon tetrachloride-induced liver cirrhosis
Increased hepatic gluconeogenesis and decreased glucose uptake, and increased hepatic de novo lipogenesis in rat model of maternal diabetes
Melatonin protects against tenofovir-induced nephrotoxicity in rats by targeting multiple cellular pathways
Mitochondrial pathway of apoptosis and necrosis contribute to tenofovir disoproxil fumarate–induced renal damage in rats
Nitrosative stress, protein tyrosine nitration, PARP activation and NAD depletion in the kidneys of rat after single dose of cyclophosphamide
Protective effect of aminoguanidine against cyclophosphamide-induced oxidative stress and renal damage in rats.
Aminoguanidine, a selective nitric oxide synthase inhibitor, attenuates cyclophosphamide-induced renal damage by inhibiting protein nitration and poly(ADP-Ribose) polymerase activation
Beneficial effects of megadoses of biotin in Streptozotocin-induced gestational diabetes mellitus in rats – A preliminary study
Oxidative damage to the lipids and proteins pf the lungs, testis and kidney of rats during carbon tetrachloride intoxication.
Normal plasma creatinine level despite histological evidence of damage and increased oxidative stress in the kidneys of cyclophosphamide treated rats.
Aminoguanidine, selective nitric oxide synthase inhibitor, ameliorates cyclophosphamide-induced hemorrhagic cystitis by inhibiting protein nitration and PARS activation.
Neutrophil infiltration and oxidative stress may play a critical role in methotrexate-induced renal damage.
Preclinical efficacy of melatonin to reduce methotrexate-induced oxidative stress and small intestinal damage in rats.
An update on diagnostic value of biotinidase: From liver damage to cancer: Minireview.
Lysosomal enzymes in the pathogenesis of carbon tetrachloride induced injury to the kidney and testis in the rat.
Oxidative damage to the hepatocellular proteins after chronic ethanol intake in the rat.
Oxidative stress in paracetamol-induced pathogenesis: (I). Renal damage.
Mega dose of vitamin C augments the nephrotoxicity of paracetamol.
Vitamin C may be beneficial in the prevention of paracetamol-induced renal damage.
Protective effect of ebselen, a selenoorganic drug, against gentamicin-induced renal damage in rats.
Does oxidative protein damage play a role in the pathogenesis of carbon tetrachloride-induced liver injury in the rat?
Role for NF-κB inflammatory signalling pathway in tenofovir disoproxil fumarate (TDF) induced renal damage in rats.
Aminoguanidine pretreatment prevents methotrexate-induced small intestinal injury in the rat by attenuating nitrosative stress and restoring the activities of vital mitochondrial enzymes
Activation of the mitochondrial apoptotic pathway contributes to methotrexate-induced small intestinal injury in rats.
Plasma prolidase may be an index of liver fibrosis in the rat.
A massive increase in serum beta-glucuronidase after a single dose of carbon tetrachloride to the rat.
Oxidative stress, decreased activities of anti-oxidant enzymes, and neutrophil infiltration contribute to Tenofovirdisoproxil fumarate induced renal damage in rats.
Oral glutamine attenuates cyclophosphamide-induced oxidative stress in the bladder but does not prevent hemorrhagic cystitis in rats
NF-κB-iNOS-COX2-TNF α inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats
Imbalance Between Peroxisomal ROS Generating Enzymes and ROS Scavenging Enzymes May Contribute to Cyclophosphamide Induced Renal Damage in Rats
Neutrophil infiltration and oxidative stress may play a critical role in methotrexate-induced renal damage.
Decrease in the activities of lysosomal enzymes may contribute to the urotoxicity of cyclophosphamide in the rat.
Evidence for the roles of oxidative stress, nitrosative stress and Nf-Kb activation in Tenofovir Disoproxil Fumarate (TDF) induced renal damage in rats
Tenofovir induced renal damage is associated with activation of NF-κB inflammatory signaling pathway and PARP overactivation.
NF-κB-iNOS-COX2-TNF α inflammatory signaling pathway plays an important role in methotrexate induced small intestinal injury in rats.
Aminoguanidine, selective nitric oxide synthase inhibitor, ameliorates cyclophosphamide-induced haemorrhagic cystitis by inhibiting protein nitration and PARS activation.
A reliable and reproducible rodent model of Tenofovir disoproxil fumarate (TDF) (anti-HIV drug) nephrotoxicity that resembles human TDF tubulopathy.
Alteration in antioxidant defense mechanisms in the small intestines of methotrexate treated rat may contribute to its gastrointestinal toxicity.
Teaching in basic sciences – A Novel approach – “Integrated Case Based Learning
Preclinical efficacy of melatonin to reduce methotrexate-induced oxidative stress and small intestinal damage in rats.
Assessment of serum biotin levels and its association with blood glucose in gestational diabetes mellitus
